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A new pathway identified to play a role in the development of acute kidney injury!
Monday, Nov 18, 2013
"A combinatorial approach of Proteomics and Systems Biology in unravelling the mechanisms of acute kidney injury (AKI): involvement of NMDA receptor GRIN1 in murine AKI."
Authors: Husi H, Sanchez-NiƱo MD, Delles C, Mullen W, Vlahou A, Ortiz A, Mischak H.
BMC Syst Biol. 2013 Oct 30;7:110.

In this paper the Glasgow group studied the changes in proteins that occur during development of acute kidney injury in a mouse model. A new pathway involving the so called NMDA receptor was identified that could play a role in the initiation and progression of kidney disease. NMDA receptors are well known from the brain where they bind neurotransmitters. Until recently there has only been limited evidence for a role of NMDA receptors in the kidney but these new data provide further evidence for this mechanism. Clearly, the data need translation to human kidney disease but if the findings can be confirmed there would already be drugs available that interfere with the NMDA receptor and that could help in the treatment of renal diseases.